Molecule Details
InChIKeyCQWBHMMWZICZRH-UHFFFAOYSA-N
Compound Name8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Canonical SMILESCC(=O)N1CCC(Nc2ncc3c(n2)-c2c(c(C(N)=O)nn2C)CC3)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL8.09
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 8.7 IC50 ChEMBL
P78396 CCNA1 Homo sapiens Human PF02984 PF00134 PF16500 8.7 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 8.4 IC50 ChEMBL;BindingDB
P06493 CDK1 Homo sapiens Human PF00069 8.3 IC50 ChEMBL;BindingDB
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 8.3 IC50 ChEMBL
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 8.2 IC50 ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 8.1 IC50 ChEMBL
Q15078 CDK5R1 Homo sapiens Human PF03261 8.1 IC50 ChEMBL;BindingDB
P49841 GSK3B Homo sapiens Human PF00069 7.5 IC50 ChEMBL;BindingDB
P28482 MAPK1 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB