Molecule Details
InChIKeyCQFVDHNTTRWVQD-UHFFFAOYSA-N
Compound Namecis-3-(3-Pyrrolidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine
Canonical SMILESNc1nccn2c(C3CC(CN4CCCC4)C3)nc(-c3cccc(OCc4ccccc4)c3)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.4
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 7.1 Ki ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 7.0 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.4 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.2 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.2 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.0 Ki ChEMBL