Molecule Details
| InChIKey | CPZBLNMUGSZIPR-NVXWUHKLSA-N |
|---|---|
| Compound Name | Palonosetron |
| Canonical SMILES | O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 9.38 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00377 |
|---|---|
| Drug Name | Palonosetron |
| CAS Number | 135729-56-5 |
| Groups | approved investigational |
| ATC Codes | A04AA55 A04AA05 |
| Description | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 h... |
Categories: Alimentary Tract and Metabolism Antidepressive Agents Antiemetic Serotonin 5-HT3 Receptor Antagonists Antiemetics Antiemetics and Antinauseants Autonomic Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Gastrointestinal Agents Heterocyclic Compounds, Fused-Ring Isoquinolines Neurotransmitter Agents Peripheral Nervous System Agents Quinuclidines Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 3 Receptor Antagonists Serotonin 5-HT3 Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists
Cross-references: BindingDB: 50417287 ChEBI: 85161 CHEMBL1189679 ChemSpider: 4892289 Drugs Product Database (DPD): 21240 D07175 PDB: O7B PharmGKB: PA10352 PubChem:6337614 PubChem:46508530 RxCUI: 70561 Therapeutic Targets Database: DAP000367 Wikipedia: Palonosetron ZINC: ZINC000003795819