Molecule Details
| InChIKey | CNIIGCLFLJGOGP-UHFFFAOYSA-N |
|---|---|
| Compound Name | Naphazoline |
| Canonical SMILES | c1ccc2c(CC3=NCCN3)cccc2c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.41 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06711 |
|---|---|
| Drug Name | Naphazoline |
| CAS Number | 835-31-4 |
| Groups | approved |
| ATC Codes | R01AB02 S01GA01 S01GA51 R01AA08 |
| Description | Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles[L5804,L5807]. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations[L5804,L5807]. Naphazoline was first developed in 1942 as a nasal formulat... |
Categories: Adrenergic Agents Adrenergic Agonists Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Cardiovascular Agents Decongestants and Antiallergics Imidazoles Nasal Decongestants Nasal Preparations Neurotransmitter Agents Ophthalmologicals Respiratory System Agents Sensory Organs Sympathomimetics Sympathomimetics Used as Decongestants Sympathomimetics, Plain Vasoconstrictor Agents
Cross-references: BindingDB: 50001922 ChEBI: 93363 CHEMBL761 ChemSpider: 4283 Drugs Product Database (DPD): 9542 D08253 PharmGKB: PA165958384 PubChem:4436 PubChem:99443263 RxCUI: 7247 Wikipedia: Naphazoline ZINC: ZINC000000119717
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 8.6 | Ki | ChEMBL;BindingDB |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 7.7 | Ki | BindingDB |
| Q9Y2I1 | NISCH | Homo sapiens | Human | PF25625 PF23142 PF00787 | 6.9 | Ki | ChEMBL;BindingDB |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 6.4 | Ki | BindingDB |