InChIKey	CMWTZPSULFXXJA-VIFPVBQESA-N
Compound Name	Naproxen
Canonical SMILES	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.42
Source	ChEMBL;BindingDB

DrugBank ID	DB00788
Drug Name	Naproxen
CAS Number	22204-53-1
Groups	approved investigational vet_approved
ATC Codes	M01AE02 M01AE57 G02CC02 M02AA12 M01AE56 M01AE52 N02CC51
Description	Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.[A178975] It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse ...

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Categories: Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antigout Preparations Antiinflammatory Preparations, Non-Steroids for Topical Use Antiinflammatory Products for Vaginal Administration Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antimigraine Preparations Antirheumatic Agents Arylpropionic acid NSAIDS BSEP/ABCB11 Substrates Central Nervous System Agents Cyclooxygenase Inhibitors Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Enzyme Inhibitors Genito Urinary System and Sex Hormones Musculo-Skeletal System Naphthaleneacetic Acids Naphthalenes Nephrotoxic agents Nervous System Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors Other Nonsteroidal Anti-inflammatory Agents P-glycoprotein inhibitors Peripheral Nervous System Agents Photosensitizing Agents Propionates Sensory System Agents Topical Products for Joint and Muscular Pain UGT1A1 Substrates UGT1A3 substrates UGT1A6 substrate UGT1A9 Substrates UGT2B7 substrates

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Cross-references: BindingDB: 50339185 ChEBI: 7476 CHEMBL154 ChemSpider: 137720 Drugs Product Database (DPD): 2037 C01517 D00118 PDB: NPS PharmGKB: PA450595 PubChem:156391 PubChem:46505508 RxCUI: 7258 Therapeutic Targets Database: DAP000968 Wikipedia: Naproxen ZINC: ZINC000000105216