Molecule Details
InChIKeyCMFVTAHMZDUCJB-GOSISDBHSA-N
Compound NameBtk-IN-17
Canonical SMILESC=CC(=O)N1CC[C@@H](N2N=C(Nc3ccc(Oc4ccccc4)cc3)c3c[nH]c4ncnc2c34)C1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL7.21
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P51813 BMX Homo sapiens Human PF00779 PF00169 PF07714 PF00017 8.6 IC50 ChEMBL
P16885 PLCG2 Homo sapiens Human PF00168 PF23329 PF23583 PF16457 PF00388 PF00387 PF00017 PF00018 8.0 IC50 ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.9 IC50 ChEMBL
Q92570 NR4A3 Homo sapiens Human PF00104 PF00105 7.8 IC50 ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.3 IC50 ChEMBL
P42681 TXK Homo sapiens Human PF07714 PF00017 PF00018 7.3 IC50 ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.7 IC50 ChEMBL
Q15303 ERBB4 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.4 IC50 ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 IC50 ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.1 IC50 ChEMBL