Molecule Details
InChIKeyCLPFFLWZZBQMAO-CQSZACIVSA-N
Compound Name4-[(5r)-5,6,7,8-Tetrahydroimidazo[1,5-A]pyridin-5-Yl]benzonitrile
Canonical SMILESN#Cc1ccc([C@H]2CCCc3cncn32)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL7.16
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB21746
Drug NameDexfadrostat
CAS Number102676-87-9
Groups investigational
ATC Codes nan
DescriptionDexfadrostat is under investigation in clinical trial NCT04007406 (DP13 - a Phase II Study in Patients With Primary Aldosteronism).
Cross-references: BindingDB: 50047262 CHEMBL287677 PDB: 0T3 ZINC: ZINC000001851916
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P19099 CYP11B2 Homo sapiens Human PF00067 8.2 IC50 ChEMBL;BindingDB
P15538 CYP11B1 Homo sapiens Human PF00067 7.1 IC50 ChEMBL;BindingDB
P11511 CYP19A1 Homo sapiens Human PF00067 6.2 IC50 ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P15538 CYP11B1 Cytochrome P450 11B1, mitochondrial inhibitor targets