Molecule Details
InChIKeyCLEGDJQQHUTCOW-UHFFFAOYSA-N
Compound Name4-Chloro-N-cyclohexyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2-pyrimidinamine
Canonical SMILESClc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)43
Pfam Stratification Cross-Family
Avg pChEMBL6.91
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (43)
Target Gene Organism Category Pfam pChEMBL Type Source
O00311 CDC7 Homo sapiens Human PF00069 9.3 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 8.4 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 8.1 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 8.1 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 8.1 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.8 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.7 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 7.5 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 7.4 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 7.3 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.0 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.9 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.9 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 6.9 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 6.9 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.8 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.8 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.8 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q02750 MAP2K1 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.7 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.6 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.6 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.6 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.5 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.4 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P53350 PLK1 Homo sapiens Human PF00069 PF00659 6.3 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.3 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.1 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.1 Ki ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 6.0 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.0 Ki ChEMBL