Molecule Details
InChIKeyCJUJLGFTKBBDMG-UHFFFAOYSA-N
Compound Name1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-(4-methyl-6-oxo-1H-pyridazin-3-yl)phenyl]urea
Canonical SMILESCc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.57
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.9 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.9 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.9 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.9 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.4 Ki ChEMBL
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 6.3 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.1 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.0 Ki ChEMBL