InChIKey	CJBJHOAVZSMMDJ-HEXNFIEUSA-N
Compound Name	Darunavir
Canonical SMILES	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	10.15
Source	BindingDB;ChEMBL

DrugBank ID	DB01264
Drug Name	Darunavir
CAS Number	206361-99-1
Groups	approved investigational
ATC Codes	J05AR14 G01AE10 J05AR22 J05AR26 J05AE10
Description	Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as [ritonavir] for the effective management of HIV-1 infection.[L9227] As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard HIV therapy.[A2278,A2281] It was initially a...

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Categories: Amides Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals used in combination for the treatment of HIV infections Carbamates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors Experimental Unapproved Treatments for COVID-19 Furans Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics HIV Protease Inhibitors Hyperglycemia-Associated Agents OATP1B1/SLCO1B1 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Protease Inhibitors Sulfonamides Sulfones Sulfur Compounds Viral Protease Inhibitors

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Cross-references: BindingDB: 8125 ChEBI: 367163 CHEMBL1323 ChemSpider: 184733 Drugs Product Database (DPD): 19793 D03656 PDB: 017 PharmGKB: PA163522472 PubChem:213039 PubChem:46506908 RxCUI: 460132 Therapeutic Targets Database: DAP001086 Wikipedia: Darunavir ZINC: ZINC000003955219