Molecule Details
InChIKeyCJAWPFJGFFNXQI-UHFFFAOYSA-N
Compound Name2-Chloro-6-(1-piperazinyl)pyrazine
Canonical SMILESClc1cncc(N2CCNCC2)n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Homologous
Avg pChEMBL6.53
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12111
Drug NameMK-212
CAS Number64022-27-1
Groups investigational
ATC Codes nan
DescriptionMK-212 has been used in trials studying the treatment of Alcoholism.

Categories: Antidepressive Agents Central Nervous System Depressants Neurotransmitter Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Receptor Agonists
Cross-references: BindingDB: 50017452 ChEBI: 92360 CHEMBL269521 ChemSpider: 97104 PubChem:107992 PubChem:347828412 Wikipedia: MK-212 ZINC: ZINC000001571800
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
P08913 ADRA2A Homo sapiens Human PF00001 6.8 Ki BindingDB
P28335 HTR2C Homo sapiens Human PF00001 6.7 Ki BindingDB
P41595 HTR2B Homo sapiens Human PF00001 6.5 Ki BindingDB
P08908 HTR1A Homo sapiens Human PF00001 6.1 Kd ChEMBL
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P28335 HTR2C 5-hydroxytryptamine receptor 2C modulator targets