Molecule Details
InChIKeyCGMQSJXTBXHOTH-UHFFFAOYSA-N
Compound NameN-(5-(3-Fluoro-4-((2-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)amino)phenyl)pyridin-2-yl)cyclopropanecarboxamide
Canonical SMILESCN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(=O)C5CC5)nc4)cc3F)cc2C(F)(F)F)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL7.58
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 9.0 IC50 ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 8.0 IC50 ChEMBL;BindingDB
P11274 BCR Homo sapiens Human PF09036 PF00168 PF19057 PF00620 PF00621 8.0 IC50 ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 8.0 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.7 IC50 ChEMBL;BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 IC50 ChEMBL;BindingDB
Q9BUB5 MKNK1 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
P21802 FGFR2 Homo sapiens Human PF07679 PF13927 PF07714 6.6 IC50 ChEMBL;BindingDB
P06730 EIF4E Homo sapiens Human PF01652 6.5 IC50 ChEMBL