InChIKey	CGIGDMFJXJATDK-UHFFFAOYSA-N
Compound Name	Indomethacin
Canonical SMILES	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	11
Pfam Stratification	Cross-Family
Avg pChEMBL	7.43
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00328
Drug Name	Indomethacin
CAS Number	53-86-1
Groups	approved investigational
ATC Codes	S01CC02 M01AB51 S01BC01 M02AA23 M01AB01 C01EB03
Description	Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemi...

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Categories: Acetic Acid Derivatives and Related Substances Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antigout Preparations Antiinflammatory Preparations, Non-Steroids for Topical Use Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents BSEP/ABCB11 Substrates Cardiac Therapy Cardiovascular Agents Central Nervous System Agents Cyclooxygenase Inhibitors Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Hypoglycemia-Associated Agents Immunosuppressive Agents Indoles Musculo-Skeletal System Myelosuppressive Agents Nephrotoxic agents Non COX-2 selective NSAIDS OAT1/SLC22A6 Substrates OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OAT3/SLC22A8 Substrates OATP1B1/SLCO1B1 Inhibitors Ophthalmologicals Other Nonsteroidal Anti-inflammatory Agents P-glycoprotein inhibitors P-glycoprotein substrates Peripheral Nervous System Agents Sensory Organs Sensory System Agents Tocolytic Agents Topical Products for Joint and Muscular Pain UGT1A1 Inhibitors UGT1A1 Substrates UGT1A9 Substrates UGT2B7 Inhibitors UGT2B7 substrates

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Cross-references: BindingDB: 17638 ChEBI: 49662 CHEMBL6 ChemSpider: 3584 Drugs Product Database (DPD): 10126 Guide to Pharmacology: 1909 IUPHAR: 1909 C01926 D00141 PDB: IMN PharmGKB: PA449982 PubChem:3715 PubChem:46508291 RxCUI: 5781 Therapeutic Targets Database: DAP000617 Wikipedia: Indometacin ZINC: ZINC000000601283