InChIKey	CBVCZFGXHXORBI-PXQQMZJSSA-N
Compound Name	Indinavir
Canonical SMILES	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	8.59
Source	BindingDB;ChEMBL

DrugBank ID	DB00224
Drug Name	Indinavir
CAS Number	150378-17-9
Groups	approved
ATC Codes	J05AE02
Description	A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]

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Categories: Agents Causing Muscle Toxicity Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use BSEP/ABCB11 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (weak) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors HIV Protease Inhibitors Hyperglycemia-Associated Agents OATP1B1/SLCO1B1 Inhibitors OCT1 inhibitors Organic Anion Transporting Polypeptide 2B1 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Protease Inhibitors Pyridines UGT1A1 Inhibitors Viral Protease Inhibitors

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Cross-references: BindingDB: 517 ChEBI: 44032 CHEMBL115 ChemSpider: 4515036 Drugs Product Database (DPD): 11269 C07051 PDB: MK1 PharmGKB: PA449977 PubChem:5362440 PubChem:46506442 RxCUI: 114289 Therapeutic Targets Database: DAP000168 Wikipedia: Indinavir ZINC: ZINC000022448696