Molecule Details
InChIKeyCBRJPFGIXUFMTM-WDEREUQCSA-N
Compound NameRitlecitinib
Canonical SMILESC=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Homologous
Avg pChEMBL6.86
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB14924
Drug NameRitlecitinib
CAS Number1792180-81-4
Groups approved investigational
ATC Codes L04AF08
DescriptionRitlecitinib (PF-06651600) is a highly selective inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family. In June 2023, it was approved by the FDA for the treatment of severe alopecia areata in adults and adolescents 12 years and older.[L4...
Categories: Antineoplastic and Immunomodulating Agents Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Immunomodulatory Agents Immunosuppressive Agents Janus Kinase 3, antagonists & inhibitors Janus Kinase Inhibitor Janus Kinase Inhibitors Janus Kinases, antagonists & inhibitors
Cross-references: BindingDB: 209866 CHEMBL4085457 ChemSpider: 59718512 Drugs Product Database (DPD): 23902 RxCUI: 2641595 Wikipedia: Ritlecitinib ZINC: ZINC000526061581
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.6 Ki ChEMBL;BindingDB
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.5 Ki BindingDB
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.5 IC50 ChEMBL;BindingDB
P42681 TXK Homo sapiens Human PF07714 PF00017 PF00018 6.8 IC50 ChEMBL;BindingDB
P51813 BMX Homo sapiens Human PF00779 PF00169 PF07714 PF00017 6.2 IC50 ChEMBL;BindingDB
P42680 TEC Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.2 IC50 ChEMBL;BindingDB
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.2 IC50 ChEMBL;BindingDB
DrugBank Target Actions (23)
Target Gene Target Name Action Type
P09488 P09488 Glutathione S-transferase Mu 1 binder enzymes
P05177 CYP1A2 Cytochrome P450 1A2 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
O14880 O14880 Glutathione S-transferase 3, mitochondrial substrate enzymes
O43708 O43708 Maleylacetoacetate isomerase substrate enzymes
P05177 CYP1A2 Cytochrome P450 1A2 substrate enzymes
P08263 GSTA1 Glutathione S-transferase A1 substrate enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P09211 GSTP1 Glutathione S-transferase P substrate enzymes
P0CG29 P0CG29 Glutathione S-transferase theta-2 substrate enzymes
P10620 P10620 Microsomal glutathione S-transferase 1 substrate enzymes
P10632 CYP2C8 Cytochrome P450 2C8 substrate enzymes
P11712 CYP2C9 Cytochrome P450 2C9 substrate enzymes
P21266 P21266 Glutathione S-transferase Mu 3 substrate enzymes
P46439 P46439 Glutathione S-transferase Mu 5 substrate enzymes
Q16772 Q16772 Glutathione S-transferase A3 substrate enzymes
Q99735 Q99735 Microsomal glutathione S-transferase 2 substrate enzymes
P42680 TEC Tyrosine-protein kinase Tec inhibitor targets
P42681 TXK Tyrosine-protein kinase TXK inhibitor targets
P51813 BMX Cytoplasmic tyrosine-protein kinase BMX inhibitor targets
P52333 JAK3 Tyrosine-protein kinase JAK3 inhibitor targets
Q06187 BTK Tyrosine-protein kinase BTK inhibitor targets
Q08881 ITK Tyrosine-protein kinase ITK/TSK inhibitor targets