Molecule Details
InChIKeyBZKPWHYZMXOIDC-UHFFFAOYSA-N
Compound NameAcetazolamide
Canonical SMILESCC(=O)Nc1nnc(S(N)(=O)=O)s1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)20
Pfam Stratification Cross-Family
Avg pChEMBL7.69
SourceBindingDB;ChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00819
Drug NameAcetazolamide
CAS Number59-66-5
Groups approved investigational vet_approved
ATC Codes G01AE10 S01EC01
DescriptionOne of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual ...

Categories: Anticonvulsants Antiglaucoma Agents Antiglaucoma Preparations and Miotics Carbonic Anhydrase Inhibitors Cardiovascular Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Diuretics Drugs causing inadvertant photosensitivity Enzyme Inhibitors Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Natriuretic Agents OAT1/SLC22A6 inhibitors Ophthalmologicals Photosensitizing Agents Sensory Organs Sulfonamides Sulfur Compounds Thiadiazoles Thiazoles
Cross-references: BindingDB: 10880 ChEBI: 27690 CHEMBL20 ChemSpider: 1909 Drugs Product Database (DPD): 6299 C06805 D00218 PDB: AZM PharmGKB: PA448018 PubChem:1986 PubChem:46504493 RxCUI: 167 Therapeutic Targets Database: DAP000600 Wikipedia: Acetazolamide ZINC: ZINC000003813042
Target Activities (20)
Target Gene Organism Category Pfam pChEMBL Type Source
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 9.1 pIC50 TTD_MultiTarget
P43166 CA7 Homo sapiens Human PF00194 8.6 Ki ChEMBL;BindingDB
O43570 CA12 Homo sapiens Human PF00194 8.2 Ki ChEMBL;BindingDB
O75493 CA11 Homo sapiens Human PF00194 8.2 Ki ChEMBL
P23280 CA6 Homo sapiens Human PF00194 8.0 Ki ChEMBL;BindingDB
P00918 CA2 Homo sapiens Human PF00194 7.9 Ki ChEMBL;BindingDB
Q8N1Q1 CA13 Homo sapiens Human PF00194 7.8 Ki ChEMBL;BindingDB
Q16790 CA9 Homo sapiens Human PF00194 7.6 Ki ChEMBL;BindingDB
Q9ULX7 CA14 Homo sapiens Human PF00194 7.4 Ki ChEMBL;BindingDB
Q9Y2D0 CA5B Homo sapiens Human PF00194 7.3 Ki ChEMBL;BindingDB
P35218 CA5A Homo sapiens Human PF00194 7.2 Ki ChEMBL;BindingDB
P22748 CA4 Homo sapiens Human PF00194 7.1 Ki ChEMBL;BindingDB
P00915 CA1 Homo sapiens Human PF00194 6.6 Ki ChEMBL;BindingDB
P07451 CA3 Homo sapiens Human PF00194 6.4 Ki ChEMBL;BindingDB
Q31FD6 Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) Pathogen PF00194 8.4 Ki ChEMBL;BindingDB
P9WPJ9 mtcA2 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Pathogen PF00484 8.1 Ki ChEMBL;BindingDB
Q3I4V7 CAN2 Cryptococcus neoformans Pathogen PF00484 8.0 Ki ChEMBL;BindingDB
Q6FTL6 NCE103 Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) Pathogen PF00484 8.0 Ki ChEMBL;BindingDB
O24855 cynT Helicobacter pylori (strain ATCC 700392 / 26695) Pathogen PF00484 7.7 Ki ChEMBL;BindingDB
P9WPJ7 mtcA1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Pathogen PF00484 6.3 Ki ChEMBL;BindingDB
DrugBank Target Actions (10)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
O43570 CA12 Carbonic anhydrase 12 inhibitor targets
P00915 CA1 Carbonic anhydrase 1 inhibitor targets
P00918 CA2 Carbonic anhydrase 2 inhibitor targets
P07451 CA3 Carbonic anhydrase 3 inhibitor targets
P22748 CA4 Carbonic anhydrase 4 inhibitor targets
P29972 P29972 Aquaporin-1 inhibitor targets
P43166 CA7 Carbonic anhydrase 7 inhibitor targets
Q9ULX7 CA14 Carbonic anhydrase 14 inhibitor targets
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inhibitor transporters