Molecule Details
| InChIKey | BWPIARFWQZKAIA-UHFFFAOYSA-N |
|---|---|
| Compound Name | Protriptyline |
| Canonical SMILES | CNCCCC1c2ccccc2C=Cc2ccccc21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.18 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00344 |
|---|---|
| Drug Name | Protriptyline |
| CAS Number | 438-60-8 |
| Groups | approved |
| ATC Codes | N06AA11 |
| Description | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood ... |
Categories: Adrenergic Agents Adrenergic Uptake Inhibitors Agents that produce hypertension Agents that reduce seizure threshold Antidepressive Agents Antidepressive Agents Indicated for Depression Antidepressive Agents, Tricyclic Benzocycloheptenes Central Nervous System Agents Central Nervous System Depressants Combined Inhibitors of Serotonin/Norepinephrine Reuptake Dibenzocycloheptenes Membrane Transport Modulators Narrow Therapeutic Index Drugs Nervous System Neurotoxic agents Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Non-Selective Monoamine Reuptake Inhibitors P-glycoprotein inhibitors Potential QTc-Prolonging Agents Psychoanaleptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators
Cross-references: BindingDB: 50176062 ChEBI: 8597 CHEMBL668 ChemSpider: 4805 Drugs Product Database (DPD): 9430 C07408 D08447 PharmGKB: PA451168 PubChem:4976 PubChem:46505128 RxCUI: 8886 Therapeutic Targets Database: DAP000863 Wikipedia: Protriptyline ZINC: ZINC000001530764