Molecule Details
InChIKeyBTFHLQRNAMSNLC-UHFFFAOYSA-N
Compound NameClorgyline
Canonical SMILESC#CCN(C)CCCOc1ccc(Cl)cc1Cl
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL8.19
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB04017
Drug NameClorgiline
CAS Number17780-72-2
Groups experimental
ATC Codes nan
DescriptionAn antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
Categories: Agents that produce hypertension Amines Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Enzyme Inhibitors Monoamine Oxidase A Inhibitors Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Monoamine Oxidase Inhibitors Propylamines Psychotropic Drugs Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 15581 ChEBI: 3763 CHEMBL8706 ChemSpider: 4227 C11685 D03248 PDB: MLG PubChem:4380 PubChem:46507410 Wikipedia: Clorgiline ZINC: ZINC000022200090
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P21397 MAOA Homo sapiens Human PF01593 8.3 IC50 ChEMBL;BindingDB
P27338 MAOB Homo sapiens Human PF01593 8.2 IC50 ChEMBL;BindingDB
Q99720 SIGMAR1 Homo sapiens Human PF04622 8.1 Ki BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P21397 MAOA Amine oxidase [flavin-containing] A inhibitor targets