Molecule Details
InChIKeyBNDYIYYKEIXHNK-UHFFFAOYSA-N
Compound Name4-(3-Hydroxyanilino)-6,7-Dimethoxyquinazoline
Canonical SMILESCOc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL7.2
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB03365
Drug Name4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 4622 CHEMBL127907 ChemSpider: 5485 PDB: DTQ PubChem:5687 PubChem:46508544 ZINC: ZINC000003828650
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P27986 PIK3R1 Homo sapiens Human PF16454 PF00620 PF00017 8.7 IC50 ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.4 IC50 ChEMBL;BindingDB
P24941 CDK2 Homo sapiens Human PF00069 7.3 pIC50 TTD_MultiTarget
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.3 IC50 ChEMBL;BindingDB
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 IC50 ChEMBL;BindingDB
Q5TCY1 TTBK1 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
P33176 KIF5B Homo sapiens Human PF00225 6.4 IC50 ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P24941 CDK2 Cyclin-dependent kinase 2 inhibitor targets
P35968 KDR Vascular endothelial growth factor receptor 2 inhibitor targets