InChIKey	BMGQWWVMWDBQGC-IIFHNQTCSA-N
Compound Name	Midostaurin
Canonical SMILES	CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	147
Pfam Stratification	Cross-Family
Avg pChEMBL	6.68
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB06595
Drug Name	Midostaurin
CAS Number	120685-11-2
Groups	approved investigational
ATC Codes	L01EX10
Description	Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward d...

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Categories: Alkaloids Antineoplastic Agents Antineoplastic and Immunomodulating Agents Carbazoles Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strong) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strong) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inducers (strong) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Inducers Cytochrome P-450 CYP3A5 Inducers (strength unknown) Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Indole Alkaloids Indoles Indolizidines Indolizines Kinase Inhibitor Narrow Therapeutic Index Drugs Protein Kinase C, antagonists & inhibitors Protein Kinase Inhibitors Receptor Tyrosine Kinase Inhibitors Tyrosine Kinase Inhibitors

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Cross-references: BindingDB: 50326053 ChEBI: 63452 CHEMBL608533 ChemSpider: 8005258 Drugs Product Database (DPD): 22883 D05029 PDB: 2K2 PubChem:9829523 PubChem:347827778 RxCUI: 1919083 Wikipedia: Midostaurin ZINC: ZINC000100013130