InChIKey	BLJRIMJGRPQVNF-JTQLQIEISA-N
Compound Name	Timolol
Canonical SMILES	CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	7.71
Source	ChEMBL;BindingDB

DrugBank ID	DB00373
Drug Name	Timolol
CAS Number	26839-75-8
Groups	approved investigational
ATC Codes	C07AA06 S01ED51 C07BA06 C07DA06 S01ED01
Description	Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by sev...

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Categories: Adrenergic Antagonists Adrenergic beta-Antagonists Agents causing hyperkalemia Alcohols Amines Amino Alcohols Antiarrhythmic agents Antiglaucoma Preparations and Miotics Antihypertensive Agents Beta Blocking Agents and Thiazides Beta Blocking Agents, Non-Selective Beta Blocking Agents, Non-Selective, and Thiazides Bradycardia-Causing Agents Cardiovascular Agents Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted EENT Drugs, Miscellaneous Hypotensive Agents Morpholines Ophthalmologicals Oxazines P-glycoprotein substrates Potential QTc-Prolonging Agents Propanolamines Propanols QTc Prolonging Agents Sulfur Compounds Thiadiazoles Thiazoles

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Cross-references: BindingDB: 50292219 ChEBI: 9599 CHEMBL499 ChemSpider: 31013 Drugs Product Database (DPD): 2292 C07141 PDB: TIM PharmGKB: PA451690 PubChem:33624 PubChem:46507733 RxCUI: 10600 Therapeutic Targets Database: DAP000088 Wikipedia: Timolol ZINC: ZINC000000002176