Molecule Details
InChIKeyBKJIXTWSNXCKJH-UHFFFAOYSA-N
Canonical SMILESCN(NC(=O)CC(=O)NN(C)C(=S)c1ccccc1)C(=S)c1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.71
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB05719
Drug NameElesclomol
CAS Number488832-69-5
Groups investigational
ATC Codes nan
DescriptionElesclomol is a novel, injectable, drug candidate that kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death. In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and an ability to stro...

Categories: Amides Sulfur Compounds
Cross-references: ChEBI: 79369 CHEMBL1972860 ChemSpider: 265501 D08909 PubChem:300471 PubChem:175427028 Wikipedia: Elesclomol ZINC: ZINC000001716098
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P07900 HSP90AA1 Homo sapiens Human PF13589 PF00183 7.7 IC50 ChEMBL
P08238 HSP90AB1 Homo sapiens Human PF13589 PF00183 7.7 IC50 ChEMBL