Molecule Details
InChIKeyBJMXICGJKUALLN-SFHVURJKSA-N
Compound Name1-[(3S)-3-[4-amino-3-(2-methyl-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
Canonical SMILESC=CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3C)c3c(N)ncnc32)C1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)8
Pfam Stratification Homologous
Avg pChEMBL7.5
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (8)
Target Gene Organism Category Pfam pChEMBL Type Source
P51813 BMX Homo sapiens Human PF00779 PF00169 PF07714 PF00017 8.9 IC50 ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 8.8 IC50 ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 8.0 IC50 ChEMBL
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 7.5 IC50 ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.5 IC50 ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.7 IC50 ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.5 IC50 ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.1 IC50 ChEMBL