Molecule Details
InChIKeyBIIVYFLTOXDAOV-UHFFFAOYSA-N
Compound Name2-(2-Chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)chromen-4-one
Canonical SMILESCN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)31
Pfam Stratification Cross-Family
Avg pChEMBL6.63
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (31)
Target Gene Organism Category Pfam pChEMBL Type Source
P50750 CDK9 Homo sapiens Human PF00069 9.2 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 8.7 Ki ChEMBL
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 7.7 IC50 ChEMBL;BindingDB
Q00535 CDK5 Homo sapiens Human PF00069 7.6 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 7.1 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.1 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 7.0 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.9 Ki ChEMBL
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.8 IC50 ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.6 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.5 Ki ChEMBL
P42679 MATK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.4 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.4 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.2 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 6.2 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.2 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.1 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.0 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.0 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.0 Ki ChEMBL
Q9P1W9 PIM2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL