Molecule Details
InChIKeyBHSOPYVVEZFHDB-UHFFFAOYSA-N
Compound Name3-[4-(3-Amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-chloro-4-methoxyphenyl)urea
Canonical SMILESCOc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)25
Pfam Stratification Cross-Family
Avg pChEMBL7.3
SourceBindingDB;ChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (25)
Target Gene Organism Category Pfam pChEMBL Type Source
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 9.4 Ki ChEMBL
Q9UBE8 NLK Homo sapiens Human PF00069 8.4 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 8.1 Ki ChEMBL
P11511 CYP19A1 Homo sapiens Human PF00067 8.1 IC50 BindingDB
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 8.1 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 8.1 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.1 IC50 ChEMBL
Q02161 RHD Homo sapiens Human PF00909 8.1 pIC50 TTD_MultiTarget
Q96GD4 AURKB Homo sapiens Human PF00069 8.1 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.9 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 7.6 IC50 ChEMBL;BindingDB
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.5 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.2 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 7.1 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.9 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.8 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.8 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.7 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.1 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.1 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.0 Ki ChEMBL