Molecule Details
InChIKeyBGQOUQWQPRPBKN-UHFFFAOYSA-N
Compound NameTRK Inhibitor 7d
Canonical SMILESCc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)N(C)CCNC(=O)CCCCO4)cc(C(F)(F)F)c2)cn1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Homologous
Avg pChEMBL7.24
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 8.0 IC50 ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 7.9 IC50 ChEMBL
Q08345 DDR1 Homo sapiens Human PF21114 PF00754 PF07714 7.6 IC50 ChEMBL
Q12866 MERTK Homo sapiens Human PF00041 PF00047 PF13927 PF07714 7.3 IC50 ChEMBL
Q15375 EPHA7 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.8 IC50 ChEMBL
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 6.7 IC50 ChEMBL
Q16832 DDR2 Homo sapiens Human PF21114 PF00754 PF07714 6.5 IC50 ChEMBL