Molecule Details
| InChIKey | BGKFPRIGXAVYNX-UHFFFAOYSA-N |
|---|---|
| Compound Name | 5,7-Dichlorokynurenic Acid |
| Canonical SMILES | O=C(O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 7 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.17 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01931 |
|---|---|
| Drug Name | 5,7-Dichlorokynurenic acid |
| CAS Number | 131123-76-7 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Excitatory Amino Acid Agents Excitatory Amino Acid Antagonists Heterocyclic Compounds, Fused-Ring Hydroxyquinolines Neurotransmitter Agents Quinolines Xanthurenates
Cross-references: BindingDB: 50001266 ChEBI: 107660 CHEMBL50267 ChemSpider: 1714 Guide to Pharmacology: 2361 IUPHAR: 2361 PDB: DK1 PubChem:1779 PubChem:46504992 Wikipedia: 5,7-Dichlorokynurenic_acid ZINC: ZINC000008660423
Target Activities (7)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O15399 | GRIN2D | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
| O60391 | GRIN3B | Homo sapiens | Human | PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
| Q05586 | GRIN1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
| Q12879 | GRIN2A | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.2 | IC50 | ChEMBL |
| Q13224 | GRIN2B | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.2 | IC50 | ChEMBL |
| Q14957 | GRIN2C | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.2 | IC50 | ChEMBL |
| Q8TCU5 | GRIN3A | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.2 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q05586 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | inhibitor | targets |