Molecule Details
| InChIKey | BDUHCSBCVGXTJM-WUFINQPMSA-N |
|---|---|
| Compound Name | Nutlin 3 |
| Canonical SMILES | COc1ccc(C2=N[C@@H](c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.38 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB17039 |
|---|---|
| Drug Name | Nutlin-3 |
| CAS Number | 548472-68-0 |
| Groups | experimental |
| ATC Codes | nan |
| Description | Nutlin-3 is a small molecule inhibitor that targets p53-Mdm2 interaction.[A253057] |
Categories: Stereoisomerism
Cross-references: BindingDB: 50229787 ChEBI: 95096 CHEMBL191334 ChemSpider: 9608062 PDB: NUT Wikipedia: Nutlin ZINC: ZINC000016051336
Target Activities (3)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P04637 | TP53 | Cellular tumor antigen p53 | inhibitor | targets |