Molecule Details
InChIKeyBCSVCWVQNOXFGL-UHFFFAOYSA-N
Compound NameZopolrestat
Canonical SMILESO=C(O)Cc1nn(Cc2nc3cc(C(F)(F)F)ccc3s2)c(=O)c2ccccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.67
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08772
Drug NameZopolrestat
CAS Number110703-94-1
Groups experimental
ATC Codes nan
Descriptionnan

Categories: Aldehyde Reductase, antagonists & inhibitors Aldose Reductase Inhibitors Blood Glucose Lowering Agents Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Pyridazines Thiazoles
Cross-references: BindingDB: 16452 CHEMBL10372 ChemSpider: 1554 C01865 PDB: ZST PubChem:1613 PubChem:99445243 ZINC: ZINC000000538557
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q04760 GLO1 Homo sapiens Human PF00903 8.9 Ki ChEMBL;BindingDB
P15121 AKR1B1 Homo sapiens Human PF00248 7.9 IC50 ChEMBL;BindingDB
O60218 AKR1B10 Homo sapiens Human PF00248 6.2 IC50 ChEMBL;BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
O60218 AKR1B10 Aldo-keto reductase family 1 member B10 binder targets
P15121 AKR1B1 Aldo-keto reductase family 1 member B1 modulator targets