6-[2-[[6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazol-5-yl]-8-methoxy-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one

InChIKey	`AZCVMDQKOWCQAG-UHFFFAOYSA-N`
Compound Name	6-[2-[[6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazol-5-yl]-8-methoxy-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one
Canonical SMILES	`COc1cc(-c2cnc(Nc3cc(N4CCN(CCO)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	8.38
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q9H0K1	SIK2	Homo sapiens	Human	PF00069 PF23312	9.2	IC50	ChEMBL
Q9Y2K2	SIK3	Homo sapiens	Human	PF00069 PF23312	8.2	IC50	ChEMBL
P57059	SIK1	Homo sapiens	Human	PF00069 PF23312	7.8	IC50	ChEMBL