Molecule Details
InChIKeyAZAANWYREOQRFB-SETSBSEESA-N
Compound NameMk-3207
Canonical SMILESO=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL10.54
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12424
Drug NameMK-3207
CAS Number957118-49-9
Groups investigational
ATC Codes nan
DescriptionMk3207 has been used in trials studying the treatment of Migraine and Migraine Disorders.
Categories: Receptors, Calcitonin Gene-Related Peptide, antagonists & inhibitors
Cross-references: BindingDB: 50356282 CHEMBL1910936 ChemSpider: 24747385 PubChem:25019940 PubChem:347828667 ZINC: ZINC000043203371
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q16602 CALCRL Homo sapiens Human PF00002 PF02793 10.7 Ki ChEMBL;BindingDB
O60894 RAMP1 Homo sapiens Human PF04901 10.7 Ki ChEMBL
P06881 CALCA Homo sapiens Human PF00214 10.3 IC50 ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q16602 CALCRL Calcitonin gene-related peptide type 1 receptor antagonist targets