Molecule Details
InChIKeyAYSXURJZVXBSRV-WJDWOHSUSA-N
Compound NameA-432411
Canonical SMILESCOc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)ccc1O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)16
Pfam Stratification Cross-Family
Avg pChEMBL6.97
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB07078
Drug Name(3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 14649 CHEMBL202930 ChemSpider: 8301349 PDB: 43A PubChem:10125830 PubChem:99443549 ZINC: ZINC000014956244
Target Activities (16)
Target Gene Organism Category Pfam pChEMBL Type Source
O14757 CHEK1 Homo sapiens Human PF00069 8.2 IC50 ChEMBL;BindingDB
P04350 TUBB4A Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
P07437 TUBB Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
P0DPH7 TUBA3C Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
P68363 TUBA1B Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
P68366 TUBA4A Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
P68371 TUBB4B Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q13509 TUBB3 Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q13885 TUBB2A Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q3ZCM7 TUBB8 Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q6PEY2 TUBA3E Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q71U36 TUBA1A Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q9BQE3 TUBA1C Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q9BUF5 TUBB6 Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q9BVA1 TUBB2B Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
Q9H4B7 TUBB1 Homo sapiens Human PF00091 PF03953 6.9 IC50 ChEMBL
DrugBank Target Actions (1)
Target Gene Target Name Action Type
O14757 CHEK1 Serine/threonine-protein kinase Chk1 inhibitor targets