Molecule Details
InChIKeyAYJBHLUSGLQYDG-UHFFFAOYSA-N
Compound Name1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-[2-fluoro-5-(hydroxymethyl)phenyl]urea
Canonical SMILESNc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(CO)ccc4F)cc3)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)16
Pfam Stratification Cross-Family
Avg pChEMBL6.84
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (16)
Target Gene Organism Category Pfam pChEMBL Type Source
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.5 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 8.3 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 8.1 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.0 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.9 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.8 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.7 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.5 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.4 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.3 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.1 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.0 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.0 Ki ChEMBL