N,6-dihydroxy-7-methoxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

InChIKey	`AYFCYVLVRYQGME-UHFFFAOYSA-N`
Compound Name	N,6-dihydroxy-7-methoxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide
Canonical SMILES	`COc1ccc(S(=O)(=O)N2CCc3cc(O)c(OC)cc3C2C(=O)NO)cc1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	9
Pfam Stratification	Homologous
Avg pChEMBL	7.41
Source	ChEMBL;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P51511	MMP15	Homo sapiens	Human	PF11857 PF00045 PF00413 PF01471	8.2	IC50	ChEMBL
P51512	MMP16	Homo sapiens	Human	PF11857 PF00045 PF00413 PF01471	7.8	IC50	ChEMBL
P39900	MMP12	Homo sapiens	Human	PF00045 PF00413 PF01471	7.7	IC50	ChEMBL
P08253	MMP2	Homo sapiens	Human	PF00040 PF00045 PF00413	7.6	pIC50	TTD_MultiTarget
P14780	MMP9	Homo sapiens	Human	PF00040 PF00045 PF00413	7.3	IC50	ChEMBL
P50281	MMP14	Homo sapiens	Human	PF11857 PF00045 PF00413 PF01471	7.2	IC50	ChEMBL
Q9NRE1	MMP26	Homo sapiens	Human	PF00413	7.1	IC50	ChEMBL
P03956	MMP1	Homo sapiens	Human	PF00045 PF00413 PF01471	6.9	IC50	ChEMBL
Q9ULZ9	MMP17	Homo sapiens	Human	PF00045 PF00413 PF01471	6.9	pIC50	TTD_MultiTarget