InChIKey	AXRYRYVKAWYZBR-GASGPIRDSA-N
Compound Name	Atazanavir
Canonical SMILES	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	7.87
Source	BindingDB;ChEMBL

DrugBank ID	DB01072
Drug Name	Atazanavir
CAS Number	198904-31-3
Groups	approved investigational
ATC Codes	J05AE08 J05AR15 J05AR23
Description	Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requir...

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Categories: Amino Acids, Peptides, and Proteins Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals used in combination for the treatment of HIV infections BSEP/ABCB11 Substrates Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors HIV Protease Inhibitors Hyperglycemia-Associated Agents Nephrotoxic agents OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors Oligopeptides Organic Anion Transporting Polypeptide 2B1 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Peptides Potential QTc-Prolonging Agents Protease Inhibitors Pyridines QTc Prolonging Agents UDP Glucuronosyltransferases Inhibitors UGT1A1 Inhibitors Viral Protease Inhibitors

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Cross-references: BindingDB: 13934 ChEBI: 37924 CHEMBL1163 ChemSpider: 130642 Drugs Product Database (DPD): 13026 D07471 PDB: DR7 PharmGKB: PA10251 PubChem:148192 PubChem:46508504 RxCUI: 343047 Therapeutic Targets Database: DNC000332 Wikipedia: Atazanavir ZINC: ZINC000003941496