Molecule Details
InChIKeyAWZFCQRICMFIES-AATRIKPKSA-N
Compound Name6-[2-[(E)-2-[4-(morpholin-4-ylmethyl)phenyl]ethenyl]pyridin-4-yl]-1,7-dihydropyrrolo[3,2-e]pyrimidin-4-one
Canonical SMILESO=c1[nH]cnc2[nH]c(-c3ccnc(/C=C/c4ccc(CN5CCOCC5)cc4)c3)cc12
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.88
SourceChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 7.6 IC50 ChEMBL
P49137 MAPKAPK2 Homo sapiens Human PF00069 7.3 IC50 ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 7.1 IC50 ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.0 IC50 ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.0 IC50 ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.5 IC50 ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.5 IC50 ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.0 IC50 ChEMBL
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 Clinical TTD_MultiTarget TTD_MultiTarget