Molecule Details
| InChIKey | AWTHUFZDVFPXSS-UHFFFAOYSA-N |
|---|---|
| Compound Name | 1-[2-Oxo-2-(hydroxyamino)ethyl]-4-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]piperidine-4-carbonitrile |
| Canonical SMILES | N#CC1(c2ccc(OC(F)F)c(OC3CCCC3)c2)CCN(CC(=O)NO)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 10.29 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 10.3 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 10.3 | IC50 | ChEMBL;BindingDB |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 10.3 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 10.3 | IC50 | ChEMBL |