Molecule Details
InChIKeyAWDORCFLUJZUQS-ZDUSSCGKSA-N
Compound NameH-1152
Canonical SMILESCc1cncc2cccc(S(=O)(=O)N3CCCNC[C@@H]3C)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Homologous
Avg pChEMBL7.01
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB07876
Drug Name(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 14028 ChEBI: 88220 CHEMBL406821 ChemSpider: 394969 PDB: H52 PubChem:448043 PubChem:99444347 ZINC: ZINC000000022706
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 8.2 Ki ChEMBL;BindingDB
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.9 IC50 ChEMBL;BindingDB
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.9 Ki BindingDB
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.6 IC50 ChEMBL;BindingDB
P17612 PRKACA Homo sapiens Human PF00069 6.5 Ki ChEMBL
P22612 PRKACG Homo sapiens Human PF00069 6.5 Ki ChEMBL
P22694 PRKACB Homo sapiens Human PF00069 6.5 Ki ChEMBL
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P17612 PRKACA cAMP-dependent protein kinase catalytic subunit alpha binder targets
P61925 P61925 cAMP-dependent protein kinase inhibitor alpha binder targets
Q13464 ROCK1 Rho-associated protein kinase 1 inhibitor targets