(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine

InChIKey	`AWDORCFLUJZUQS-UHFFFAOYSA-N`
Compound Name	(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine
Canonical SMILES	`Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	22
Pfam Stratification	Cross-Family
Avg pChEMBL	6.62
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O75116	ROCK2	Homo sapiens	Human	PF25346 PF00069 PF08912	8.1	Ki	ChEMBL
P51817	PRKX	Homo sapiens	Human	PF00069	7.8	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	7.5	IC50	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.4	Ki	ChEMBL
Q8TDC3	BRSK1	Homo sapiens	Human	PF21122 PF00069 PF21115	7.1	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	6.8	Ki	ChEMBL
P17612	PRKACA	Homo sapiens	Human	PF00069	6.7	Ki	ChEMBL
Q7KZI7	MARK2	Homo sapiens	Human	PF02149 PF00069 PF00627	6.7	Ki	ChEMBL
P53667	LIMK1	Homo sapiens	Human	PF00412 PF00595 PF07714	6.6	Ki	ChEMBL
Q13131	PRKAA1	Homo sapiens	Human	PF16579 PF21147 PF00069	6.6	Ki	ChEMBL
P15735	PHKG2	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
P27448	MARK3	Homo sapiens	Human	PF02149 PF00069 PF00627	6.5	Ki	ChEMBL
Q05655	PRKCD	Homo sapiens	Human	PF00130 PF21494 PF00069 PF00433	6.5	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	6.4	Ki	ChEMBL
Q13188	STK3	Homo sapiens	Human	PF11629 PF00069	6.2	Ki	ChEMBL
O15530	PDPK1	Homo sapiens	Human	PF14593 PF00069	6.1	Ki	ChEMBL
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	6.1	Ki	ChEMBL
Q16513	PKN2	Homo sapiens	Human	PF02185 PF00069 PF00433	6.1	Ki	ChEMBL
O96017	CHEK2	Homo sapiens	Human	PF00498 PF00069	6.0	Ki	ChEMBL
Q13237	PRKG2	Homo sapiens	Human	PF00027 PF00069	6.0	Ki	ChEMBL
Q13976	PRKG1	Homo sapiens	Human	PF00027 PF16808 PF00069	6.0	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL