Molecule Details
InChIKeyAWDJJMXJUOHGLC-UHFFFAOYSA-N
Compound NameGsk-356278
Canonical SMILESCCn1ncc2c(NC3CCOCC3)c(-c3nnc(Cc4sc(C)nc4C)o3)cnc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.57
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12542
Drug NameGSK-356278
CAS Number720704-34-7
Groups investigational
ATC Codes nan
DescriptionGsk356278 has been used in trials studying the treatment and basic science of Anxiety Disorders, Huntington Disease, Depressive Disorder, Huntingtons Disease, and Depressive Disorder, Major, among others.

Categories: Oxazoles Sulfur Compounds
Cross-references: ChemSpider: 8428126 PubChem:10252640 PubChem:347828768 ZINC: ZINC000038428932
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13946 PDE7A Homo sapiens Human PF00233 9.1 IC50 ChEMBL
Q13370 PDE3B Homo sapiens Human PF00233 8.3 IC50 ChEMBL
Q14432 PDE3A Homo sapiens Human PF00233 8.3 IC50 ChEMBL
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P27815 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A inhibitor targets
Q07343 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B inhibitor targets
Q08499 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D inhibitor targets