Molecule Details
InChIKeyAVZCPICCWKMZDT-UHFFFAOYSA-N
Compound NameGsk-J1
Canonical SMILESO=C(O)CCNc1cc(N2CCc3ccccc3CC2)nc(-c2ccccn2)n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Cross-Family
Avg pChEMBL6.95
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
O15550 KDM6A Homo sapiens Human PF02373 PF21322 PF21326 PF13181 7.3 IC50 ChEMBL
O15054 KDM6B Homo sapiens Human PF02373 PF21322 PF21326 7.2 IC50 ChEMBL;BindingDB
Q15910 EZH2 Homo sapiens Human PF21358 PF11616 PF18118 PF18264 PF00856 7.2 IC50 ChEMBL
Q9UGL1 KDM5B Homo sapiens Human PF01388 PF02373 PF02375 PF21323 PF00628 PF08429 PF02928 6.8 IC50 ChEMBL;BindingDB
P41229 KDM5C Homo sapiens Human PF01388 PF02373 PF02375 PF21323 PF00628 PF08429 PF02928 6.3 IC50 ChEMBL