Molecule Details
| InChIKey | AVUQEUZIEFWTDC-HNNXBMFYSA-N |
|---|---|
| Compound Name | 1,3-dimethyl-4-[3-[(3S)-1-methylsulfonylpyrrolidin-3-yl]oxyanilino]pyrazolo[3,4-b]pyridine-5-carboxamide |
| Canonical SMILES | Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(O[C@H]4CCN(S(C)(=O)=O)C4)c3)c12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.6 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 6.6 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 6.6 | IC50 | ChEMBL;BindingDB |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 6.6 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 6.6 | IC50 | ChEMBL |