InChIKey	AUZONCFQVSMFAP-UHFFFAOYSA-N
Compound Name	Disulfiram
Canonical SMILES	CCN(CC)C(=S)SSC(=S)N(CC)CC
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	6.5
Source	ChEMBL;BindingDB

DrugBank ID	DB00822
Drug Name	Disulfiram
CAS Number	97-77-8
Groups	approved investigational
ATC Codes	P03AA04 P03AA54 N07BB01
Description	A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by fl...

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Categories: Acetyl Aldehyde Dehydrogenase Inhibitors Acids, Acyclic Agents that reduce seizure threshold Alcohol Deterrents Aldehyde Dehydrogenase Inhibitor Antiparasitic Products, Insecticides and Repellents BSEP/ABCB11 Substrates Carbamates Central Nervous System Agents Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Disulfides Drugs Used in Addictive Disorders Drugs Used in Alcohol Dependence Ectoparasiticides, Incl. Scabicides Ectoparasiticides, Incl. Scabicides, Insecticides and Repellents Enzyme Inhibitors Nervous System Potential QTc-Prolonging Agents QTc Prolonging Agents Sulfides Sulfur Compounds Sulfur Containing Products Thiocarbamates

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Cross-references: BindingDB: 50058655 ChEBI: 4659 CHEMBL964 ChemSpider: 3005 Drugs Product Database (DPD): 5805 C01692 D00131 PharmGKB: PA449376 PubChem:3117 PubChem:46506008 RxCUI: 3554 Therapeutic Targets Database: DAP000012 Wikipedia: Disulfiram ZINC: ZINC000001529266