Molecule Details
InChIKeyATLYLVPZNWDJBW-KIHHCIJBSA-N
Canonical SMILESNC(=O)c1cccc([C@H]2C[C@H]3CC[C@@H](C2)N3CCN(CC2CCCCC2)C(=O)[C@@H](O)CO)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL8.45
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12013
Drug NameAxelopran
CAS Number949904-48-7
Groups investigational
ATC Codes nan
DescriptionAxelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation.
Categories: Acids, Carbocyclic Alkaloids Amides Aza Compounds Azabicyclo Compounds Benzene Derivatives Benzoates Opioid Antagonists
Cross-references: CHEMBL3137313 ChemSpider: 31444004 PubChem:67156338 PubChem:347828331 Wikipedia: Axelopran
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P35372 OPRM1 Homo sapiens Human PF00001 9.9 Ki ChEMBL;BindingDB
P41143 OPRD1 Homo sapiens Human PF00001 7.0 Ki ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P35372 OPRM1 Mu-type opioid receptor modulator targets