Molecule Details
| InChIKey | ASPOIVQEUUCDQT-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | N#[C][Fe-2]([C]#N)([C]#N)([C]#N)([C]#N)[N]=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.15 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00325 |
|---|---|
| Drug Name | Nitroprusside |
| CAS Number | 15078-28-1 |
| Groups | approved investigational |
| ATC Codes | C02DD01 |
| Description | Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. |
Categories: Anions Antihypertensive Agents Arteriolar Smooth Muscle, Agents Acting On Cardiovascular Agents Compounds used in a research, industrial, or household setting Cyanides Direct Vasodilators Drugs that are Mainly Renally Excreted Electrolytes Ferric Compounds Ferricyanides Hypotensive Agents Indicators and Reagents Ions Iron Compounds Laboratory Chemicals Methemoglobinemia Associated Agents Nitrates and Nitrites Nitric Oxide Donors Nitroferricyanide Derivatives Nitrogen Compounds Vasodilating Agents Vasodilation
Cross-references: BindingDB: 50377921 ChEBI: 7596 CHEMBL2097081 ChemSpider: 21607452 Drugs Product Database (DPD): 5525 C07269 PharmGKB: PA451406 PubChem:11963622 PubChem:46508965 RxCUI: 7476 Therapeutic Targets Database: DNC001351 Wikipedia: Sodium_nitroprusside
Target Activities (2)
DrugBank Target Actions (7)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P04798 | CYP1A1 | Cytochrome P450 1A1 | inhibitor | enzymes |
| P16066 | NPR1 | Atrial natriuretic peptide receptor 1 | agonist | targets |
| Q14571 | ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | antagonist | targets |
| Q14573 | ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | antagonist | targets |
| Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | antagonist | targets |
| Q02108 | GUCY1A1 | Guanylate cyclase soluble subunit alpha-1 | modulator | targets |
| Q02153 | GUCY1B1 | Guanylate cyclase soluble subunit beta-1 | modulator | targets |