Molecule Details
| InChIKey | ASNFTDCKZKHJSW-REOHCLBHSA-N |
|---|---|
| Compound Name | Quisqualic Acid |
| Canonical SMILES | N[C@@H](Cn1oc(=O)[nH]c1=O)C(=O)O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.25 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB02999 |
|---|---|
| Drug Name | Quisqualic acid |
| CAS Number | 52809-07-1 |
| Groups | experimental |
| ATC Codes | nan |
| Description | Quisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of _Quisq... |
Categories: Amino Acids Amino Acids, Peptides, and Proteins Excitatory Amino Acid Agents Excitatory Amino Acid Agonists Neurotransmitter Agents Oxadiazoles Oxazoles
Cross-references: BindingDB: 86211 ChEBI: 8734 CHEMBL279956 ChemSpider: 37038 Guide to Pharmacology: 1372 IUPHAR: 1372 C08296 PDB: QUS PubChem:40539 PubChem:46509075 Wikipedia: Quisqualic_acid ZINC: ZINC000000897456
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q16099 | GRIK4 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 8.2 | Ki | BindingDB |
| Q13255 | GRM1 | Homo sapiens | Human | PF00003 PF01094 PF10606 PF07562 | 7.5 | Ki | BindingDB |
| P41594 | GRM5 | Homo sapiens | Human | PF00003 PF01094 PF10606 PF07562 | 7.4 | Ki | ChEMBL;BindingDB |
| Q14832 | GRM3 | Homo sapiens | Human | PF00003 PF01094 PF07562 | 6.6 | Ki | BindingDB |
| Q14416 | GRM2 | Homo sapiens | Human | PF00003 PF01094 PF07562 | 6.6 | Ki | BindingDB |
DrugBank Target Actions (8)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q13255 | GRM1 | Metabotropic glutamate receptor 1 | agonist | targets |
| P42262 | GRIA2 | Glutamate receptor 2 | binder | targets |
| Q13002 | GRIK2 | Glutamate receptor ionotropic, kainate 2 | binder | targets |
| P39086 | GRIK1 | Glutamate receptor ionotropic, kainate 1 | inhibitor | targets |
| P41594 | GRM5 | Metabotropic glutamate receptor 5 | inhibitor | targets |
| Q04609 | FOLH1 | Glutamate carboxypeptidase 2 | inhibitor | targets |
| Q14416 | GRM2 | Metabotropic glutamate receptor 2 | inhibitor | targets |
| Q14832 | GRM3 | Metabotropic glutamate receptor 3 | inhibitor | targets |