Molecule Details
| InChIKey | APYXQTXFRIDSGE-UHFFFAOYSA-N |
|---|---|
| Compound Name | Bisindolylmaleimide III |
| Canonical SMILES | NCCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.33 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB07457 |
|---|---|
| Drug Name | 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE |
| CAS Number | nan |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: BindingDB: 2691 ChEBI: 41059 CHEMBL270875 ChemSpider: 2305 PDB: BI3 PubChem:2398 PubChem:99443928 ZINC: ZINC000002560261
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q13557 | CAMK2D | Homo sapiens | Human | PF08332 PF00069 | 6.4 | IC50 | ChEMBL;BindingDB |
| P17612 | PRKACA | Homo sapiens | Human | PF00069 | 6.3 | IC50 | ChEMBL |
| P22612 | PRKACG | Homo sapiens | Human | PF00069 | 6.3 | IC50 | ChEMBL |
| P22694 | PRKACB | Homo sapiens | Human | PF00069 | 6.3 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| O15530 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | binder | targets |