1-[7-[[2-(3,5-dichloroanilino)-5-(1-methylpyrazol-4-yl)pyrimidin-4-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoroethanone

InChIKey	`APMWOAUECKVBTF-UHFFFAOYSA-N`
Compound Name	1-[7-[[2-(3,5-dichloroanilino)-5-(1-methylpyrazol-4-yl)pyrimidin-4-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoroethanone
Canonical SMILES	`Cn1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2Nc2ccc3c(c2)CN(C(=O)C(F)(F)F)CC3)cn1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	7.57
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q12866	MERTK	Homo sapiens	Human	PF00041 PF00047 PF13927 PF07714	7.9	IC50	ChEMBL;BindingDB
Q06418	TYRO3	Homo sapiens	Human	PF00041 PF07679 PF07714	7.6	IC50	ChEMBL;BindingDB
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	7.2	IC50	ChEMBL;BindingDB