Molecule Details
| InChIKey | AOMZDQMIOCTPQP-CFSTZTOESA-N |
|---|---|
| Canonical SMILES | CC(C)(C)NC(=O)[C@@H]1CN(Cc2cc3ccccc3o2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)NC1c2ccccc2C[C@H]1O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.89 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB02009 |
|---|---|
| Drug Name | L-756423 |
| CAS Number | 216863-66-0 |
| Groups | investigational |
| ATC Codes | nan |
| Description | nan |
Categories: Antiviral Agents HIV Protease Inhibitors Indenes
Cross-references: BindingDB: 50109714 CHEMBL151663 ChemSpider: 4589714 PDB: L75 PubChem:5481481 PubChem:46508445 ZINC: ZINC000024447427
Target Activities (2)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P04585 | gag-pol | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) | Pathogen | PF00540 PF19317 PF00552 PF02022 PF00075 PF00665 PF00077 PF00078 PF06815 PF06817 PF00098 | 9.3 | IC50 | BindingDB |
| Q72874 | pol | Human immunodeficiency virus type 1 | Pathogen | PF00077 | 8.5 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P03366 | gag-pol | Gag-Pol polyprotein | inhibitor | targets |