methyl 2-hydroxy-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethyl]-1H-indole-6-carboxylate

InChIKey	`AMHUBFWCCMLLCJ-UHFFFAOYSA-N`
Compound Name	methyl 2-hydroxy-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethyl]-1H-indole-6-carboxylate
Canonical SMILES	`COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	15
Pfam Stratification	Homologous
Avg pChEMBL	7.69
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	8.7	IC50	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	8.5	IC50	ChEMBL
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	8.4	IC50	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	8.3	IC50	ChEMBL
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	8.2	IC50	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	7.9	IC50	ChEMBL
P16234	PDGFRA	Homo sapiens	Human	PF07679 PF25305 PF07714	7.8	IC50	ChEMBL
P09619	PDGFRB	Homo sapiens	Human	PF00047 PF13927 PF25305 PF07714	7.5	IC50	ChEMBL
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	7.5	IC50	ChEMBL
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	7.4	IC50	ChEMBL
P21802	FGFR2	Homo sapiens	Human	PF07679 PF13927 PF07714	7.3	IC50	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	7.3	IC50	ChEMBL
P22607	FGFR3	Homo sapiens	Human	PF21165 PF07679 PF13927 PF07714	7.0	IC50	ChEMBL
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	7.0	IC50	ChEMBL
P22455	FGFR4	Homo sapiens	Human	PF07679 PF13927 PF07714	6.4	IC50	ChEMBL